Renal damage in mice after treatment with cisplatinum alone or in combination with X-irradiation

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(86)90387-1· OSTI ID:5090946

Stewart, F; Bohlken, S; Begg, A; Bartelink, H

Functional kidney damage in mice was measured (using clearance of 51Cr-EDTA) from 1 to 39 weeks after treatment with single doses of cisplatinum (c-DDP), X rays, or their combination. After c-DDP alone renal damage was observed within 1 week. From 1 to 7 weeks there was recovery of function after low drug doses but after doses in excess of 6 mg/kg some damage persisted. After irradiation alone there was no measurable change in function for 20 weeks. Beyond this time there was a dose dependent and progressive deterioration of function. c-DDP given before or after irradiation caused more damage than either agent alone. During the first 20 weeks independent toxicities accounted for most of this effect but at later times modification of radiation damage possibly contributed. The greatest enhancements were observed when c-DDP was given 1/2 hour before to 1 day after irradiation (Dose Modifying Factor, DMF, 1.3). c-DDP given 3 to 4 weeks before X rays caused only a slight enhancement of damage (DMF 1.1).

• OSTI ID: 5090946
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMOTHERAPY
CHROMIUM 51
CHROMIUM ISOTOPES
CLEARANCE
EDTA
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOTOPES
KIDNEYS
MAMMALS
MEDICINE
MICE
NUCLEAR MEDICINE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RENAL CLEARANCE
RODENTS
THERAPY
TOXICITY
VERTEBRATES
X RADIATION