Intrahepatic distribution of plutonium in beagles
Journal Article
·
· Radiat. Res.; (United States)
Beagle dogs were exposed by inhalation to a /sup 238/PuO/sub 2/ aerosol or by intravenous injection to /sup 238/Pu or /sup 239/Pu-citrate and the distribution of Pu in liver was measured (t = 64-1553 days) after exposure. Random distribution of plutonium at early times after exposure was changed to clustering of activity at times beyond 2 years after inhalation exposure. The distribution of Pu in liver at the cellular level from high levels of Pu exposure was not the same as that at lower levels of exposure such as those most likely to be encountered by man. Particles were found in liver sections of animals that died by 1350 days after exposure by inhalation to a mean initial lung burden of 0.97 ..mu..Ci/kg body wt. This indicated that for high initial lung burdens, particle transfer can occur. At low levels of exposure, distributions of plutonium deposited in liver after translocation from lung and after intravenous injection were similar for at least 4 months after exposure.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 6700239
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AUTORADIOGRAPHY
BIOLOGICAL ACCUMULATION
BODY
CARBOXYLIC ACID SALTS
CHALCOGENIDES
CITRATES
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INHALATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
LUNGS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM 238
PLUTONIUM 239
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
TISSUE DISTRIBUTION
TRANSURANIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AUTORADIOGRAPHY
BIOLOGICAL ACCUMULATION
BODY
CARBOXYLIC ACID SALTS
CHALCOGENIDES
CITRATES
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INHALATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
LUNGS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM 238
PLUTONIUM 239
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
TISSUE DISTRIBUTION
TRANSURANIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES