Clinical and biological differences between recurrent herpes simplex virus and varicella-zoster virus infections

Journal Article · Fri Dec 01 00:00:00 EST 1989 · JAMA, Journal of the American Medical Association; (USA)

DOI:https://doi.org/10.1001/jama.1989.03430240091037· OSTI ID:6699541

Straus, S E ^[1]

---

1. National Institute of Allergy and Infectious Diseases, Bethesda, MD (USA)

The major features that distinguish recurrent herpes simplex virus infections from zoster are illustrated in this article by two case histories. The clinical and epidemiologic features that characterize recurrent herpes simplex virus and varicella-zoster virus infections are reviewed. It is noted that herpesvirus infections are more common and severe in patients with cellular immune deficiency. Each virus evokes both humoral and cellular immune response in the course of primary infection. DNA hybridization studies with RNA probes labelled with sulfur-35 indicate that herpes simplex viruses persist within neurons, and that varicella-zoster virus is found in the satellite cells that encircle the neurons.

• OSTI ID: 6699541
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Vol. 262:24; ISSN 0098-7484
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GANGLIONS
AUTORADIOGRAPHY
HERPES SIMPLEX
PATHOGENESIS
HERPES ZOSTER
MESSENGER-RNA
DNA HYBRIDIZATION
VIRAL DISEASES
MOLECULAR BIOLOGY
INFECTIOUS DISEASES
PATIENTS
SULFUR 35
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
HYBRIDIZATION
ISOTOPES
LIGHT NUCLEI
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RNA
SKIN DISEASES
SULFUR ISOTOPES
550201* - Biochemistry- Tracer Techniques