Preliminary studies on the fibrogenic effects of silicotic pulmonary lavage in normal rat lung
Journal Article
·
· J. Environ. Sci. Health, Part A; (United States)
The biological activity of silica free broncho-pulmonary lavage (BPL) obtained from silicotic rats was determined by injecting intratracheally into fresh group of rats or by exposure to a suspension of sheep erythrocytes. The BPL obtained at 8, 16 and 45 days after silica inoculation, revealed no hemolytic action on sheep red blood corpuscles. However, when injected intratracheally into fresh rats, the BPL caused mild exudative and cellular changes into the alveolar spaces at early periods. At later periods, marked interstitial thickening due to infiltration by mononuclear cells, foamy macrophages and fibroblasts resulted. The 16 day old silicotic BPL involved larger areas of pulmonary parenchyma and caused more fibroblastic proliferation as compared to BPL obtained at other periods.
- Research Organization:
- Industrial Toxicology Research Centre, Lucknow, India
- OSTI ID:
- 6698296
- Journal Information:
- J. Environ. Sci. Health, Part A; (United States), Journal Name: J. Environ. Sci. Health, Part A; (United States) Vol. A21:4; ISSN JESED
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
ERYTHROCYTES
FIBROBLASTS
LAVAGE
LUNGS
MAMMALS
MATERIALS
MINERALS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM
RODENTS
RUMINANTS
SHEEP
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SOMATIC CELLS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
DOMESTIC ANIMALS
ERYTHROCYTES
FIBROBLASTS
LAVAGE
LUNGS
MAMMALS
MATERIALS
MINERALS
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RATS
RESPIRATORY SYSTEM
RODENTS
RUMINANTS
SHEEP
SILICA
SILICON COMPOUNDS
SILICON OXIDES
SOMATIC CELLS
TOXICITY
VERTEBRATES