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Failure of low doses of /sup 131/I to ablate residual thyroid tissue following surgery for thyroid cancer

Conference · · Radiology; (United States)
OSTI ID:6687669
;

Thirteen patients received an initial dose of 25-29.9 mCi (925-1106 MBq) of /sup 131/I following partial thyroidectomy for papillary, follicular, or mixed carcinoma. Administration of thyroxine (T/sub 4/) or triiodothyronine (T/sub 3/) was stopped 3-12 weeks and 1-6 weeks, respectively, before therapy or imaging. Patients remained on normal diets and did not receive thyroid stimulating hormone (TSH) or diuretics. Follow-up 3 months to 2 years after therapy demonstrated that ablation of thyroid bed activity was successful in only one patient, who still had metastases. This suggests that administration of 25-29.9 mCi of /sup 131/I following surgery is unreliable for ablation of residual thyroid bed activity.

Research Organization:
Veterans Administration Medical Center, Denver, CO
OSTI ID:
6687669
Journal Information:
Radiology; (United States), Journal Name: Radiology; (United States) Vol. 137:3; ISSN RADLA
Country of Publication:
United States
Language:
English

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Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DIET
DISEASES
DOSES
ENDOCRINE GLANDS
EVALUATION
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MEDICAL SURVEILLANCE
MEDICINE
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION DOSES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOTHERAPY
SURGERY
SURVEILLANCE
THERAPY
THYROID
THYROID HORMONES
THYROIDECTOMY
THYROXINE
TRIIODOTHYRONINE
TSH