Serial TSH determination after T/sub 3/ withdrawal or thyroidectomy in the therapy of thyroid carcinoma. [I-131]
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5825357
Exogenous triiodothyronine (T/sub 3/) was substituted for levothyroxin or desiccated thyroid in 13 athyrotic patients previously treated for papillary, follicular, or mixed papillary-follicular carcinoma of the thyroid. After 4 weeks, T/sub 3/ therapy was discontinued and serial determinations of plasma thyroid stimulating hormone (TSH) concentrations were made. A roughly exponential rise in TSH values, corresponding to a doubling time of 2 days, was observed until a level of 40 ..mu..IU/ml was reached, after which the curve passed through a maximum at 20 days. The mean time required for a level of 50 ..mu..IU/ml was 11 days, and this time is suggested for TSH determination before I-131 imaging of patients with thyroid cancer. Plasma TSH values in eight patients following total thyroidectomy showed a much slower and more variable rise, with a mean doubling time of 7.6 days. Weekly TSH levels beginning at 15 days will provide a rational basis for I-131 imaging in this group, in whom a longer period of hypothyroidism will be required before imaging and therapy. Adherence to these protocols should minimize the duration of hypothyroidism in patients undergoing I-131 treatment of thyroid carcinoma.
- Research Organization:
- Univ. of Arizona, Tucson
- OSTI ID:
- 5825357
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
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INDUCTION OF NEOPLASMS IN THYROID GLANDS OF RATS BY SUBTOTAL THYROIDECTOMY AND BY THE INJECTION OF ONE MICROCURIE OF I$sup 13$$sup 1$
The advantages of subtotal thyroidectomy and suppression of TSH in the primary treatment of papillary carcinoma of the thyroid
Conference
·
Sun Nov 30 23:00:00 EST 1980
· Radiology; (United States)
·
OSTI ID:6687669
INDUCTION OF NEOPLASMS IN THYROID GLANDS OF RATS BY SUBTOTAL THYROIDECTOMY AND BY THE INJECTION OF ONE MICROCURIE OF I$sup 13$$sup 1$
Journal Article
·
Tue Dec 31 23:00:00 EST 1963
· Cancer Research (U.S.)
·
OSTI ID:4100286
The advantages of subtotal thyroidectomy and suppression of TSH in the primary treatment of papillary carcinoma of the thyroid
Journal Article
·
Sat Jun 01 00:00:00 EDT 1985
· Cancer (Philadelphia); (United States)
·
OSTI ID:5021271
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CLEARANCE
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HORMONES
HYPOTHYROIDISM
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SURGERY
THERAPY
THYROID
THYROID HORMONES
THYROIDECTOMY
TRACER TECHNIQUES
TRIIODOTHYRONINE
TSH
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CLEARANCE
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HORMONES
HYPOTHYROIDISM
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SURGERY
THERAPY
THYROID
THYROID HORMONES
THYROIDECTOMY
TRACER TECHNIQUES
TRIIODOTHYRONINE
TSH