Survival of thyroid cells: in vivo irradiation and in situ repair

Journal Article · Mon Dec 01 04:00:00 EST 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575490· OSTI ID:6686786

Mulcahy, R T; Gould, M N; Clifton, K H

The survival of rat thyroid cell irradiated in vivo and removed immediately for transplantation survival assay was compared with results obtained previously for thyroid cells irradiated in vitro and with the survival of thyroid cells irradiated and left in situ for 24 h before transplantation survival assay. The D/sub 0/ for thyroid cells irradiated in vivo and removed immediately for assay is 195 rad; N is 4 and D/sub q/ is 270 rad. These parameters are not significantly different from those obtained when thyroid cells are irradiated in vitro. When these parameters are compared to those of thyroid cells irradiated and left in situ for 24 h, the latter have a greater N and D/sub q/, but there is no significant difference in D/sub 0/. These data provide further evidence for a form of repair of potentially lethal damage which is dependent on the tissue environment (in situ repair, ISR) as previously described for irradiated rat mammary gland cells.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 6686786
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL KILLING
COMPARATIVE EVALUATIONS
ELECTROMAGNETIC RADIATION
IN VITRO
IN VIVO
IONIZING RADIATIONS
MAMMALS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RECOVERY
REPAIR
RODENTS
SURVIVAL CURVES
THYROID CELLS
VERTEBRATES
X RADIATION