Fecal /sup 13/C analysis for the detection and quantitation of intestinal malabsorption

Journal Article · · J. Lab. Clin. Med.; (United States)

OSTI ID:6681529

Klein, P D; MacLean, Jr, W C; Watkins, J B

Use of /sup 14/CO/sub 2/ breath tests and fecal analyses for the detection and quantitation of intestinal malabsorption has been extensively documented in adult subjects. The use of radioisotopes has extended the range of breath test applications to include pediatric and geriatric subjects. Here we report a fecal /sup 13/C analysis that can be used in conjunction with /sup 14/CO/sub 2/ breath tests. Twenty-four-hour fecal samples were collected before and after the administration of a labeled substrate. Simultaneous cholyglycine /sup 13/CO/sub 2/ breath tests and fecal assays were performed in five children. One child with bacterial overgrowth had an abnormal breath test and a normal fecal test. Of three children with ileal dysfunction, only one had an abnormal breath test, whereas the fecal test was abnormal in all three. Both the breath test and fecal test were abnormal for a child who had undergone an ileal resection. Both tests were normal for a child with ulcerative colitis.

• Research Organization: Univ. of Chicago, IL
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6681529
• Journal Information: J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 97; ISSN JLCMA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
AMINO ACIDS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBON 13
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON ISOTOPES
CARBON OXIDES
CARBOXYLIC ACIDS
CHALCOGENIDES
DIAGNOSIS
DIGESTIVE SYSTEM DISEASES
DISEASES
EVEN-ODD NUCLEI
FECES
INTESTINAL ABSORPTION
ISOTOPE RATIO
ISOTOPES
LIGHT NUCLEI
MATERIALS
METABOLISM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
STABLE ISOTOPES
UPTAKE
WASTES