Measurement of fecal /sup 14/C excretion

Journal Article · Mon Nov 01 04:00:00 EST 1982 · J. Nucl. Med.; (United States)

OSTI ID:6531715

Kumaran, K A; Wiener, N S; Katz, J B

Simultaneous measurements of fecal /sup 14/C and expired /sup 14/CO/sub 2/ in the breath are necessary to evaluate patients with various ileal abnormalities and bile salt malabsorption. Following the oral ingestion of the labeled bile acid, glycine-(I-/sup 14/C)cholic acid, detection of increased fecal /sup 14/C without abnormal expiration of /sup 14/CO/sub 2/ identifies patients with ileal resection. This contrasts with the normal fecal /sup 14/C content and abnormal expired /sup 14/CO/sub 2/ found in patients with bacterial overgrowth. Fecal /sup 14/C content was determined by utilizing Van Slyke combustion of the specimen and trapping the liberated /sup 14/CO/sub 2/ with Scintisorb C. The method is simple, rapid, and accurate, and expands the diagnostic usefulness of the bile salt absorption test.

• Research Organization: The Mt. Sinai Medical Center, Cleveland, Ohio
• OSTI ID: 6531715
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
BILE ACIDS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARBOXYLIC ACIDS
CHALCOGENIDES
CHOLIC ACID
DIAGNOSIS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
FECES
GASTROINTESTINAL TRACT
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
INTESTINES
LABELLED COMPOUNDS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATIENTS
SMALL INTESTINE
STEROIDS
STEROLS
UPTAKE
USES
WASTES