Effects of mutagenized X chromosomes of Drosophila melanogaster on viability and fitness in males
Drosophila melanogaster males were treated with different doses of X-rays or ethyl methanesulfonate (EMS) and mated so that mutagenized X chromosomes could be recovered and tested for lethal mutations affecting viability and other aspects of fitness. The Poisson-corrected frequencies of the lethal mutations increased linearly with dose for both X-rays and EMS. Based on the data, l Krad X-rays given acutely induces the same number of lethals as 0.55 mM EMS administered by feeding. For some of the X-ray and EMS doses, the mutagenized chromosomes that were nonlethal reduced the viability of their carriers by a small amount, but there was no discernable dose-effect relationship. However in every case where a viability effect was seen, the percentage reduction was less than the corresponding frequency of lethals. All the groups of mutagenized nonlethal chromosomes reduced overall fitness by a significant percentage. Wherever a meaningful comparison was possible, this reduction was 2-3 times the reduction in viability, but as in the viability data, no dose-effect relationship was discernable.
- Research Organization:
- Univ. of Minnesota, St. Paul
- OSTI ID:
- 6678497
- Journal Information:
- Environ. Mutagen.; (United States), Vol. 6:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DROSOPHILA
GENETIC RADIATION EFFECTS
EMS
GENETIC EFFECTS
LETHAL MUTATIONS
RADIOINDUCTION
DOSE-RESPONSE RELATIONSHIPS
MALES
VIABILITY
X CHROMOSOME
X RADIATION
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMES
DIPTERA
ELECTROMAGNETIC RADIATION
ESTERS
FLIES
FRUIT FLIES
HETEROCHROMOSOMES
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
MUTAGENS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
SULFONIC ACID ESTERS
560154* - Radiation Effects on Animals- Basic Studies- (-1987)
550400 - Genetics
560304 - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)