Effects of mutagenized X chromosomes of Drosophila melanogaster on viability and fitness in males

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860060303· OSTI ID:6678497

Simmons, M J; Raymond, J D; Anklesaria, F X; Hawkins, E T; Johnson, N A; Cooper, J S; Cox, N M

Drosophila melanogaster males were treated with different doses of X-rays or ethyl methanesulfonate (EMS) and mated so that mutagenized X chromosomes could be recovered and tested for lethal mutations affecting viability and other aspects of fitness. The Poisson-corrected frequencies of the lethal mutations increased linearly with dose for both X-rays and EMS. Based on the data, l Krad X-rays given acutely induces the same number of lethals as 0.55 mM EMS administered by feeding. For some of the X-ray and EMS doses, the mutagenized chromosomes that were nonlethal reduced the viability of their carriers by a small amount, but there was no discernable dose-effect relationship. However in every case where a viability effect was seen, the percentage reduction was less than the corresponding frequency of lethals. All the groups of mutagenized nonlethal chromosomes reduced overall fitness by a significant percentage. Wherever a meaningful comparison was possible, this reduction was 2-3 times the reduction in viability, but as in the viability data, no dose-effect relationship was discernable.

• Research Organization: Univ. of Minnesota, St. Paul
• OSTI ID: 6678497
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:3; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMOSOMES
DIPTERA
DOSE-RESPONSE RELATIONSHIPS
DROSOPHILA
ELECTROMAGNETIC RADIATION
EMS
ESTERS
FLIES
FRUIT FLIES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HETEROCHROMOSOMES
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
LETHAL MUTATIONS
MALES
MUTAGENS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
SULFONIC ACID ESTERS
VIABILITY
X CHROMOSOME
X RADIATION