Effects of inhaled nitrogen dioxide and diesel exhaust on developing lung. Research report, January 1984-October 1986
Technical Report
·
OSTI ID:6677164
This study examined the physiological response of both developing and mature rats to inhaled automotive emissions. A total of 384 rats in two age groups (from conception to 6 months and from 6 months to 12 months) were exposed to either 9.5 ppm nitrogen dioxide (NO/sub 2/) or 3.5 mg/cu m of diesel exhaust soot for 7 hours/day, 5 days/week over a six-month period. Body weight, respiratory function, pulmonary immune response, lung clearance of radiolabeled particles, airway fluid enzymes, lung tissue collagen, proteinase, lung burden of diesel soot, lung morphometry, and histopathology were measured. The study concluded that normal lung development was not affected by NO/sub 2/ or diesel exhaust soot. In adults, clearance of soot from the lungs was slower, with the persistence of aggregated macrophages in the alveoli and evidence of septal thickening. Adults exposed to soot or NO/sub 2/ showed a sixfold increase in the percentage of neutrophils in the airways fluid.
- Research Organization:
- Health Effects Inst., Cambridge, MA (USA)
- OSTI ID:
- 6677164
- Report Number(s):
- PB-88-234398/XAB; HEI/RR-87/08
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of inhaled nitrogen dioxide and diesel exhaust on developing lung
Influence of experimental pulmonary emphysema on the toxicological effects from inhaled nitrogen dioxide and diesel exhaust
Influence of preexisting pulmonary emphysema on susceptibility of rats to inhaled diesel exhaust
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Research Report Health Effects Institue; (USA)
·
OSTI ID:5223361
Influence of experimental pulmonary emphysema on the toxicological effects from inhaled nitrogen dioxide and diesel exhaust
Journal Article
·
Sun Oct 01 00:00:00 EDT 1989
· Research Report Health Effects Institue; (USA)
·
OSTI ID:6982840
Influence of preexisting pulmonary emphysema on susceptibility of rats to inhaled diesel exhaust
Journal Article
·
Tue May 01 00:00:00 EDT 1990
· American Review of Respiratory Disease (New York); (USA)
·
OSTI ID:7011382
Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
CHALCOGENIDES
DIESEL ENGINES
DISEASES
DOCUMENT TYPES
ENGINES
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
GROWTH
HEAT ENGINES
HISTOLOGY
IMMUNOLOGY
INTERNAL COMBUSTION ENGINES
LABORATORY ANIMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PROGRESS REPORT
RESPIRATION
RESPIRATORY SYSTEM DISEASES
WASTES
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
CHALCOGENIDES
DIESEL ENGINES
DISEASES
DOCUMENT TYPES
ENGINES
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
GROWTH
HEAT ENGINES
HISTOLOGY
IMMUNOLOGY
INTERNAL COMBUSTION ENGINES
LABORATORY ANIMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PROGRESS REPORT
RESPIRATION
RESPIRATORY SYSTEM DISEASES
WASTES