Isozyme composition of lactate dehydrogenase of rat skeletal muscles after flight in Kosmos-690 biosatellite. [Effects of radiation on lactate dehydrogenase]

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Space Biol. Med. (USSR) (Engl. Transl.); (United States)

OSTI ID:6677062

Petrova, N V

Rats in a ground-based model experiment, in which all flight conditions with the exception of weightlessness and accelerations and intact animals maintained under vivarium conditions served as a control. On the 10th day of flight and of the ground-based model experiments, the rats were exposed to 800 rad radiation for 24 h. Samples of soleus and plantaris muscles were taken for examination on the 2d and 27th days after landing and termination of the ground-based model experiment. Intact animals were sacrificed on the same days as experimental ones. Samples of muscle tissue were frozen in dry ice and stored for several days at a temperature of -70/sup 0/ before they were studied. This investigation of isozyme spectrum of LDH of skeletal muscles of rats from the Kosmos-690 satellite indicates that the changes in proportion of isozyme fractions of LDH on the 2d day after the flight are due to the effects of weightlessness; subsequent changes (27th day) in correlation between LDH fraction activity are related to the effects of radiation.

• OSTI ID: 6677062
• Journal Information: Space Biol. Med. (USSR) (Engl. Transl.); (United States), Journal Name: Space Biol. Med. (USSR) (Engl. Transl.); (United States) Vol. 1; ISSN SBMEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSATELLITES
DEHYDROGENASES
ENZYMES
ISOENZYMES
LACTATE DEHYDROGENASE
MAMMALS
MUSCLES
OXIDOREDUCTASES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SATELLITES
SPACE FLIGHT
VERTEBRATES