Susceptibility to virus infection with exposure to nitrogen dioxide. Research report, January 1984-July 1987
The interaction between nitrogen dioxide (NO/sub 2/) exposure and human susceptibility to respiratory virus infection was investigated in a placebo-controlled, randomized, blinded trial conducted in an environmentally controlled research chamber. Healthy, nonsmoking volunteers, 18 to 35 years old, who were seronegative to influenza A/Korea/82 (H/sub 3/N/sub 2/) virus, breathed either filtered air or NO/sub 2/ for two hours a day for three consecutive days. Live, attenuated cold-adapted influenza A/Korea/82 reassortant virus was administered intranasally to all subjects after the second day of exposure. No adverse changes in pulmonary function or nonspecific airway reaction to methacholine were observed after NO/sub 2/ exposure, virus infection, or both. Although the differences were not statistically significant, the groups exposed to NO/sub 2/ in year 3 became infected more often (91%) than those exposed only to air (71%).
- Research Organization:
- Health Effects Inst., Cambridge, MA (USA)
- OSTI ID:
- 6677057
- Report Number(s):
- PB-88-234463/XAB; HEI/RR-88/15
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
BIOLOGICAL EFFECTS
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
INFECTIOUS DISEASES
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PROGRESS REPORT
VIRAL DISEASES