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Induction of endogenous murine retrovirus by hydroxyurea and related compounds

Journal Article · · Virology; (United States)
;
Hydroxyurea and two related compounds, carbamoyloxyurea and formamidoxime, induce endogenous retrovirus expression in AKR mouse embryo cells. Only the induction of ecotropic (N-tropic).virus was detected. The ability of each compound to induce shows a linear dose-response over a limited range of concentrations which correlate with the cytotoxicity of each of the compounds. The data suggest that these compounds may induce virus expression via damage to cellular DNA.
Research Organization:
Oak Ridge National Lab., TN
OSTI ID:
6670978
Journal Information:
Virology; (United States), Journal Name: Virology; (United States) Vol. 87:1; ISSN VIRLA
Country of Publication:
United States
Language:
English

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Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMIDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
DNA
DOSE-RESPONSE RELATIONSHIPS
EMBRYONIC CELLS
HYDROXY COMPOUNDS
HYDROXYUREA
MAMMALS
MICE
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
RODENTS
VERTEBRATES
VIRUSES