V-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

Journal Article · Wed Feb 01 04:00:00 EST 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.4.1168· OSTI ID:5037220

Langdon, W Y; Klinken, S P ^[1]; Hartley, J W; Morse, III, H C ^[2]; Ruscetti, S K ^[3]

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1. Walter and Eliza Hall Institute of Medical Research, Parkville (Australia) National Institute of Allergy and Infectious Diseases, Bethesda, MD (USA)
2. National Institute of Allergy and Infectious Diseases, Bethesda, MD (USA)
3. National Cancer Institute, Bethesda, MD (USA)

Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.

• OSTI ID: 5037220
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 86:4; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
CARBOXYLIC ACIDS
CELL TRANSFORMATIONS
CLONING
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
DRUGS
EVEN-ODD NUCLEI
FIBROBLASTS
GENES
GENETIC MAPPING
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
ISOTOPES
LIGHT NUCLEI
LIPOTROPIC FACTORS
LYMPHOMAS
MAMMALS
MAN
MAPPING
METHIONINE
MICE
MICROORGANISMS
MOLECULAR STRUCTURE
NEOPLASMS
NUCLEI
ONCOGENES
ONCOGENIC TRANSFORMATIONS
ONCOGENIC VIRUSES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARASITES
PRIMATES
PROTEINS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
SULFUR 35
SULFUR ISOTOPES
VERTEBRATES
VIRUSES