Radiation-induced alterations in the distribution of lysosomal hydrolases in rat spleen homogenates. [Gamma radiation]

Journal Article · Sat Jul 01 00:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574871· OSTI ID:6670103

Snyder, S L; Eklund, S K

Whole-body exposure of rats to /sup 60/Co-..gamma.. radiation results in increases in the activities of two lysosomal hydrolases, ..beta..-glucuronidase and ..cap alpha..-fucosidase, found in the supernatant fraction of spleen homogenates. The redistribution of these enzymes from the ''particulate-bound'' to the ''free-supernatant'' fraction of spleen homogenates has been studied as a function of radiation dose. The response curves for the ratio of free/bound enzyme versus dose sigmoidal with maximum occurring at 300 to 400 rad.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD
• OSTI ID: 6670103
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 75:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL CONSTITUENTS
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENZYMES
GAMMA RADIATION
HYDROLASES
IONIZING RADIATIONS
LYSOSOMES
MAMMALS
METABOLISM
ORGANOIDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SPLEEN
VERTEBRATES