Phtoactivation of polynuclear hydrocarbons

Journal Article · Mon Feb 01 04:00:00 EST 1965 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1965.10663990· OSTI ID:6667503

Epstein, S S

This review presented some incomplete studies with these objectives: (1) to study photodynamic mechanisms as a parameter of activity of polynuclear carcinogens; (2) to determine the nature of the correlation existing between photodynamic and carcinogenic activities in the class of polynuclear compounds; and (3) to determine whether the degree of photodynamic activity of crude organic mixtures, such as air pollutants, could provide a useful and rapid measure of presumptive carcinogenic hazard to man, attributable to polynuclear compounds. Log-phase cells of cloned cultures of Paramecium caudatum, grown axenically in the dark at 28/sup 0/C in a semi-synthetic medium of low protein content, provided the standard source of test cells. The limited data presented suggested that bioassay may provide a biological index of potential carcinogenic hazard attributable to polycyclic compounds. However, evaluation of this concept demands correlated photodynamic, carcinogenic, and chemical studies on numerous samples and fractions of organic air pollutants collected from sources exemplifying a wide epidemiological spectrum of respiratory tract cancer. 24 references, 5 figures, 2 tables.

• OSTI ID: 6667503
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 10; ISSN AEHLA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
AROMATICS
BIOASSAY
BIOLOGICAL EFFECTS
CARCINOGENS
CHEMISTRY
CILIATA
HAZARDS
HEALTH HAZARDS
HYDROCARBONS
INVERTEBRATES
MICROORGANISMS
ORGANIC COMPOUNDS
PARAMECIUM
PHOTOCHEMISTRY
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
PROTOZOA
TOXICITY