Association between photodynamic and carcinogenic activities in polycyclic compounds

Journal Article · Mon Jun 01 04:00:00 EDT 1964 · Cancer Res.; (United States)

OSTI ID:5017630

Epstein, S S; Small, M; Falk, H L; Mantel, N

The photodynamic activities of 157 polycyclic compounds of wide structural range were determined, with the use of Paramecium caudatum. High photodynamic activity was largely confined to polycyclic compounds, either homocyclic or heterocyclic, with four or five fused rings. Significant absorption of light was shown to be prerequisite but not sufficient for high photodynamic activity. A significant statistical association between photodynamic activity and carcinogenicity was demonstrated. It was shown that compounds with high photodynamic activity had 4 times greater odds of being carcinogenic than compounds with low activity. However, the photodynamic assay cannot identify a particular polycyclic compound as being carcinogenic or noncarcinogenic.

• Research Organization: Children's Hospital, Boston, MA
• OSTI ID: 5017630
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 24:5; ISSN CNREA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AMINES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
CARCINOGENS
CHEMISTRY
CILIATA
DATA
EXPERIMENTAL DATA
FEDERAL REGION III
HYDROCARBONS
INFORMATION
INVERTEBRATES
MAMMALS
MAN
MARYLAND
MEASURING INSTRUMENTS
MICROORGANISMS
NORTH AMERICA
NUMERICAL DATA
ORGANIC COMPOUNDS
PARAMECIUM
PHOTOCHEMICAL OXIDANTS
PHOTOCHEMISTRY
PHOTOSENSITIVITY
POLLUTION
POLYCYCLIC AROMATIC AMINES
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
PROTOZOA
SENSITIVITY
SPECTROPHOTOMETERS
USA
VERTEBRATES