Hydrogen-deuterium exchange studies utilizing a thermospray mass spectrometer interface
Journal Article
·
· Anal. Chem.; (United States)
A routine and efficient technique was developed for exchanging acidic hydrogen for deuterium, utilizing a thermospray mass spectrometer interface, to produce deuterium-enriched deuteron-adduct molecular and fragment ions. Samples dissolved in solvents containing acidic deuterium atoms (D/sub 2/O/trifluoroacetic acid-d/sub 1/ or ammonium acetate-d/sub 4/) were introduced via slug injection into the thermospray interface sandwiched between slugs of the deuteriated solvent. At all other times, the carrier solvent system introduced into the mass spectrometer consisted of a non-deuterium-enriched mixture. Deuterium enrichments achieved were greater than 95%. Deuterium-enriched deuteron-adduct molecular and fragment ions enabled the determination of the number of acidic hydrogens and aided in structural elucidation of model compounds of pharmaceutical interest.
- Research Organization:
- American Cyanamid Company, Pearl River, NY (USA)
- OSTI ID:
- 6661572
- Journal Information:
- Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 60:19; ISSN ANCHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
ADDUCTS
AMINO ACIDS
CARBOXYLIC ACIDS
DATA
DEUTERIUM
DEUTERIUM COMPOUNDS
EXPERIMENTAL DATA
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
INFORMATION
ISOTOPE ENRICHED MATERIALS
ISOTOPES
ISOTOPIC EXCHANGE
LIGHT NUCLEI
MASS SPECTROSCOPY
MATERIALS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
SPECTROSCOPY
STABLE ISOTOPES
400102* -- Chemical & Spectral Procedures
400202 -- Isotope Effects
Isotope Exchange
& Isotope Separation
ADDUCTS
AMINO ACIDS
CARBOXYLIC ACIDS
DATA
DEUTERIUM
DEUTERIUM COMPOUNDS
EXPERIMENTAL DATA
HYDROGEN COMPOUNDS
HYDROGEN ISOTOPES
INFORMATION
ISOTOPE ENRICHED MATERIALS
ISOTOPES
ISOTOPIC EXCHANGE
LIGHT NUCLEI
MASS SPECTROSCOPY
MATERIALS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
SPECTROSCOPY
STABLE ISOTOPES