Effects of gamma-aminobutyric acid agonist and antagonist drugs on local cerebral glucose utilization

Journal Article · Thu Jul 01 04:00:00 EDT 1982 · J. Neurosci.; (United States)

OSTI ID:6657431

Palacios, J M; Kuhar, M J; Rapoport, S I; London, E D

The (/sup 14/C)2-deoxy-D-glucose method of Sokoloff et al. was used to study local cerebral glucose utilization (LCGU) in rats treated with gamma-aminobutyric acid (GABA) agonist (muscimol and 4,5,6,7-tetrahydroisoxazolo(5,4-C)pyridin-3-ol, THIP) and antagonist (bicuculline) drugs. It was of interest to determine if the pattern of LCGU responses to GABA agonists and antagonists administered systemically in vivo would reflect the known distributions of markers for central GABAergic synapses. The patterns of LCGU responses to muscimol and THIP generally were similar. Most brain regions showed dose-dependent decreases in LCGU; others showed no effects; but the red nucleus showed an increase. The GABA antagonist bicuculline produced convulsions and variable LCGU responses, depending on the time of administration. Bicuculline also partially antagonized the depressant effects of muscimol of LCGU. The magnitudes and distribution of in vivo cerebral metabolic responses to specific GABA agonists were not correlated simply with markers for GABAergic synapses. This lack of correlation indicates that additional factors, such as neural circuitry, regulate the LCGU responses to GABAergic drugs.

• Research Organization: Laboratory of Neuroscience, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland
• OSTI ID: 6657431
• Journal Information: J. Neurosci.; (United States), Journal Name: J. Neurosci.; (United States) Vol. 2:7; ISSN JNRSD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ALKALOIDS
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CEREBRUM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GLUCOSE
HEXOSES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHARMACOLOGY
PHYSIOLOGY
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SACCHARIDES
VERTEBRATES