Determination of nicotine by surface-enhanced Raman scattering (SERS)
- Health Sciences Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6113 (United States)
The analytical application of surface-enhanced Raman spectroscopy (SERS) to the determination of nicotine is demonstrated. A simple spectroelectrochemical method using a copper or silver electrode as the SERS substrate has been developed, consisting of three steps: polishing a working electrode to a mirror finish; roughening the electrode in an electrolyte solution; and, finally, depositing the nicotine analyte onto the roughened electrode after immersion in a sample solution. During the reduction cycle, a large enhancement in nicotine Raman scattering is observed at the electrode surface. The intensity of the SERS signal on a silver electrode is linear with concentration from 10 to 900 ppb, with an estimated detection limit of 7 ppb. The total analysis time per sample is approximately five minutes. This procedure has been used to analyze the extract from a cigarette side-stream smoke sample (environmental tobacco smoke); the SERS results agree well with those of conventional gas chromatographic analysis.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6651967
- Journal Information:
- Applied Spectroscopy; (United States), Vol. 48:11; ISSN 0003-7028
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
ENVIRONMENTAL EFFECTS
TOBACCO SMOKES
AIR POLLUTION
ELECTROCHEMICAL COATING
NICOTINE
PH VALUE
QUANTITATIVE CHEMICAL ANALYSIS
RAMAN SPECTROSCOPY
AEROSOLS
ALKALOIDS
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
AZOLES
CHEMICAL ANALYSIS
CHEMICAL COATING
COLLOIDS
DEPOSITION
DISPERSIONS
DRUGS
HETEROCYCLIC COMPOUNDS
LASER SPECTROSCOPY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
POLLUTION
PYRIDINES
PYRROLES
PYRROLIDINES
RESIDUES
SMOKES
SOLS
SPECTROSCOPY
SURFACE COATING
540120* - Environment
Atmospheric- Chemicals Monitoring & Transport- (1990-)
400102 - Chemical & Spectral Procedures