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Technetium-99m calcium phytate - optimization of calcium content for liver and spleen scintigraphy: concise communication

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6643740
; ; ;
The addition of ionic calcium to technetium-99m stannous phytate produced an agent with improved splenic uptake. In a series of patients, it was found that molar ratios of 2:1 and 3:1 produced scans of optimal diagnostic quality. Studies in mice showed dose-related changes in the biodistribution. Electron microscopy demonstrated that the addition of calcium produced progressive aggregation of the colloid as the molar ratio was increased. Chemical analysis of sodium phytate was essential to obtain accurate ratios.
Research Organization:
Inst. of Medical and Veterinary Science, Adelaide, South Australia
OSTI ID:
6643740
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:2; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
BODY
CALCIUM
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
ELEMENTS
ESTERS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LIPOTROPIC FACTORS
LIVER
MAMMALS
METABOLISM
METALS
MICE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PATIENTS
PERFORMANCE TESTING
PHOSPHORIC ACID ESTERS
PHYTIC ACID
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RODENTS
SCINTISCANNING
SPLEEN
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTING
TISSUE DISTRIBUTION
UPTAKE
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES