Local control and reduced complications in split course irradiation of prostatic cancer
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
- Johns Hopkins Hospital, Baltimore, MD
Split course prostatic irradiation is a treatment technique where 4000 to 4500 rad whole pelvis irradiation is followed by two weeks of rest and additional 2000 to 2500 rad by reduced field technique to a total dose of 6000 to 6500 rad. Eighty-four patients were studied and the results indicated a local regional control rate of 97.6% with an overall 3 year survival without evidence of disease of 96.6% for Stages A and B and 60% for Stage C. Significant complications occurred in 1.2% of the patients. None of the patients needed surgical correction of a complication other than a perineal abscess. The risk/benefit ratio for pelvic and prostatic irradiation favors split course prostatic irradiation in that it demonstrates a low complication rate, high local regional control, and comparable disease-free survival to continuous irradiation.
- OSTI ID:
- 6643414
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:1; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLANDS
HAZARDS
HEALTH HAZARDS
IRRADIATION
MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SURVIVAL CURVES
THERAPY
TUMOR CELLS
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLANDS
HAZARDS
HEALTH HAZARDS
IRRADIATION
MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SURVIVAL CURVES
THERAPY
TUMOR CELLS