Evaluation of split-course irradiation for pelvic malignancies

Journal Article · Fri Feb 01 04:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90034-6· OSTI ID:5072206

Parsons, J T; Thar, T L; Bova, F J; Million, R R

Therapeutic results of split-course vs continuous-course whole pelvis irradiation were analyzed in 235 consecutive patients with carcinoma of the uterine cervix, prostate, or urinary bladder. Eighty-six patients with carcinoma of the cervix were assigned randomly to receive either split or continuous treatment; 65 patients with prostate cancer and 84 patients with bladder cancer were not randomized. Except for a planned 14 to 16 day interruption after 2800 to 3000 rad in the split-course group, the techniques of irradiation did not differ. For each tumor site, local control for the 2 techniques was similar when total doses were the same. No significant differences in survival were noted. Paradoxically, in both the randomized and non-randomized groups, the occurrence of radiation-induced chronic gastrointestinal injury was more frequent in patients who were treated by the split-course technique.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 5072206
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
CARCINOMAS
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DIGESTIVE SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
GLANDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALE GENITALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PATIENTS
PROSTATE
RADIATION EFFECTS
RADIATION SYNDROME
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL CURVES
THERAPY
URINARY TRACT
UROGENITAL SYSTEM DISEASES
YEARS LIVING RADIOISOTOPES