Inactivation of human and simian rotaviruses by chlorine dioxide

Journal Article · Tue May 01 00:00:00 EDT 1990 · Applied and Environmental Microbiology; (USA)

OSTI ID:6639166

Chen, Yu-Shiaw ^[1]; Vaughn, J M ^[2]

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1. Brookhaven National Lab., Upton, NY (USA)
2. Univ. of New England College of Medicine, Biddeford, ME (USA)

The inactivation of single-particle stocks of human (type 2, Wa) and simian (SA-11) rotaviruses by chlorine dioxide was investigated. Experiments were conducted at 4{degree}C in a standard phosphate-carbonate buffer. Both virus types were rapidly inactivated, within 20 s under alkaline conditions, when chlorine dioxide concentrations ranging from 0.05 to 0.2 mg/liter were used. Similar reductions of 10{sup 5}-fold in infectivity required additional exposure time of 120 s at 0.2 mg/liter for Wa and at 0.5 mg/liter for SA-11, respectively, at pH 6.0. The inactivation of both virus types was moderate a neutral pH, and the sensitivities to chlorine dioxide were similar. The observed enhancement of virucidal efficiency with increasing pH was contrary to earlier findings with chlorine- and ozone-treated rotavirus particles, where efficiencies decreased with increasing alkalinity. Comparison of 99.9% virus inactivation times revealed ozone to be the most effective virucidal agent among these three disinfectants.

• OSTI ID: 6639166
• Journal Information: Applied and Environmental Microbiology; (USA), Journal Name: Applied and Environmental Microbiology; (USA) Vol. 56:5; ISSN 0099-2240; ISSN AEMID
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CHALCOGENIDES
CHLORINE
CHLORINE COMPOUNDS
CHLORINE OXIDES
COMPARATIVE EVALUATIONS
ELEMENTS
HALOGEN COMPOUNDS
HALOGENS
INACTIVATION
MAMMALS
MAN
MICROORGANISMS
MONKEYS
NONMETALS
OXIDES
OXYGEN COMPOUNDS
OZONE
PARASITES
PH VALUE
PRIMATES
TOXICITY
VERTEBRATES
VIRUSES