Allopurinol therapy and cataractogenesis in humans
Journal Article
·
· Am. J. Ophthalmol.; (United States)
Long-term ingestion of allopurinol, an antihyperuricemic agent used to treat gout, may be related to the development of lens opacities in relatively young patients (second to fifth decades of life). Cataracts obtained from three patients taking allopurinol were subjected to high-resolution phosphorescence spectroscopy. The characteristic allopurinol triplet was demonstrated in all three cataracts. Identical spectra were obtained for normal human lenses incubated in media containing 10(-3)M allopurinol and exposed to 1.2 mW/cm2 ultraviolet radiation for 16 hours; control lenses (irradiated without allopurinol) showed no allopurinol triplets. Similar data were obtained for lenses from rats given one dose of allopurinol and exposed to ultraviolet radiation overnight. These data provide evidence that allopurinol can be photobound in rat and human lenses and suggest its cataractogenic potential.
- Research Organization:
- Department of Ophthalmology, Emory University, Atlanta, GA
- OSTI ID:
- 6638206
- Journal Information:
- Am. J. Ophthalmol.; (United States), Journal Name: Am. J. Ophthalmol.; (United States) Vol. 94:2; ISSN AJOPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AZINES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CATARACTS
CHEMOTHERAPY
CRYSTALLINE LENS
DISEASES
ELECTROMAGNETIC RADIATION
ETIOLOGY
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PYRIMIDINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
SENSE ORGANS
SENSE ORGANS DISEASES
SIDE EFFECTS
THERAPY
ULTRAVIOLET RADIATION
550900 -- Pathology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AZINES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CATARACTS
CHEMOTHERAPY
CRYSTALLINE LENS
DISEASES
ELECTROMAGNETIC RADIATION
ETIOLOGY
EYES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PYRIMIDINES
RADIATIONS
RADIOSENSITIVITY EFFECTS
SENSE ORGANS
SENSE ORGANS DISEASES
SIDE EFFECTS
THERAPY
ULTRAVIOLET RADIATION