Psoralen--long-wave ultraviolet therapy and human cataractogenesis
Cataract formation associated with psoralen--long-wave ultraviolet (P-UVA) therapy has been documented in experimental animals. Presumptive P-UVA cataracts in humans have also been reported recently. Cataracts from two patients on P-UVA therapy were subjected to high-resolution phosphorescence spectroscopy. The lens homogenates from these two patients showed phosphorescence peaks identical (in shape and lifetime) with the previously reported 8-methoxypsoralen lens protein photoproduct seen in P-UVA-treated cataractous rat lenses. The data provide objective proof that these phototherapeutic drugs can generate specific P-UVA photoproducts in human lenses. Similar photoproducts have previously been demonstrated in experimental (rat) P-UVA cataracts.
- Research Organization:
- Department of Ophthalmology, Emory University, Atlanta, GA
- OSTI ID:
- 6239935
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 23:6; ISSN IOVSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTICOAGULANTS
BODY
BODY AREAS
CATARACTS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COUMARINS
CRYSTALLINE LENS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATIENTS
PHOTOCHEMICAL REACTIONS
PSORALEN
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SENSE ORGANS DISEASES
SIDE EFFECTS
THERAPY
ULTRAVIOLET RADIATION