Cytotoxic effects of sodium selenite on tadpoles (Xenopus laevis)
Journal Article
·
· Arch. Environ. Contam. Toxicol.; (United States)
The cytotoxic effects of sodium selenite on developing tadpoles (Xenopus laevis) were examined by scanning, light, and electron microscopy. Selenium exposure resulted in disorganization, vacuolization, and swelling of the outer layer of epithelial cells in the tadpole epidermis. Examination of muscle cells in the somites revealed myofibril disorganization and cell degeneration. Mitochondria in both epithelial and muscle cells were swollen and showed loss of cristae. It is likely that sublethal exposures to selenium compounds result in cellular damage which could affect motility, and thus survival, over longer periods of time.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 6637893
- Journal Information:
- Arch. Environ. Contam. Toxicol.; (United States), Journal Name: Arch. Environ. Contam. Toxicol.; (United States) Vol. 9; ISSN AECTC
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550500 -- Metabolism
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMPHIBIANS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
ELECTRON MICROSCOPY
EPIDERMIS
EPITHELIUM
LARVAE
MICROSCOPY
MITOCHONDRIA
ORGANOIDS
ORGANS
SELENITES
SELENIUM COMPOUNDS
SKIN
SURVIVAL TIME
TISSUES
TOXICITY
VERTEBRATES
560304* -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMPHIBIANS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
ELECTRON MICROSCOPY
EPIDERMIS
EPITHELIUM
LARVAE
MICROSCOPY
MITOCHONDRIA
ORGANOIDS
ORGANS
SELENITES
SELENIUM COMPOUNDS
SKIN
SURVIVAL TIME
TISSUES
TOXICITY
VERTEBRATES