Free radical formation in vivo and hepatotoxicity due to anesthesia with halothane
Journal Article
·
· Anesthesiology; (United States)
In vivo studies were undertaken to determine whether free radical formation in the liver during administration of various halogenated anesthetics is associated with hepatotoxicity of these agents in an animal model. In addition to the anesthetics halothane, enflurane, and isoflurane, carbon tetrachloride was studied as an example of a hepatotoxic halogenated compound acting by a free radical mechanism. Free radicals were trapped in vivo during anesthesia as stable adducts using the spin trap, alpha-phenyl-t-butyl nitrone. These adducts were extracted from the liver and studied by electron spin resonance spectrometry. Free radicals were detected after administration of halothane or carbon tetrachloride, compounds which were hepatotoxic under the conditions of the experiment, but were not found after anesthesia induced with enflurane or isoflurane, anesthetics which were not hepatotoxic under identical conditions. The free radical trapped after alpha-phenyl-t-butyl nitrone treatment of halothane-anesthetized rats appeared to be a metabolic intermediate of halothane.
- Research Organization:
- Department of Anaesthesia, Flinders Medical Centre, University of Adelaide, South Australia
- OSTI ID:
- 6637696
- Journal Information:
- Anesthesiology; (United States), Journal Name: Anesthesiology; (United States) Vol. 57:3; ISSN ANESA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
552000 -- Public Health
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
ANESTHETICS
ANIMALS
BIOLOGICAL PATHWAYS
BODY
CARBON TETRACHLORIDE
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORINATED ALIPHATIC HYDROCARBONS
DIGESTIVE SYSTEM
DRUGS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
IN VIVO
LIVER
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADICALS
RATS
RODENTS
SENSITIVITY
SIDE EFFECTS
TOXICITY
VERTEBRATES
552000 -- Public Health
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
ANESTHETICS
ANIMALS
BIOLOGICAL PATHWAYS
BODY
CARBON TETRACHLORIDE
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORINATED ALIPHATIC HYDROCARBONS
DIGESTIVE SYSTEM
DRUGS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
IN VIVO
LIVER
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADICALS
RATS
RODENTS
SENSITIVITY
SIDE EFFECTS
TOXICITY
VERTEBRATES