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Acute effects of inhaled SO/sub 2/ plus NaCl droplet aerosol on pulmonary function in asthmatic adolescents

Journal Article · · Environ. Res.; (United States)
OSTI ID:6637127
; ;
Nine adolescent subjects with a diagnosis of extrinsic asthma were exposed at rest for 60 min to the following experimental modes: (a) filtered air; (b) 1 ppM of sulfur dioxide (SO/sub 2/) and 1 mg/m/sup 3/ of sodium chloride (NaCl) droplet aerosol; c 1 mg/m/sup 3/ of NaCl droplet aerosol alone. All exposures were at 75% relative humidity and 22/sup 0/C temperature. Functional measurements of total respiratory resistance (R/sub tau/), maximal flow at 50 and 75% of expired vital capacity (V/sub max 50/ and V/sub max 75/), forced expiratory volume in 1 sec (FEV/sub 1.0/) and functional residual capacity (FRC) were recorded before, during, and after exposures. Significant decreases in V/sub max 50/ and V/sub max 75/ were seen when the group was exposed to the SO/sub 2/ plus NaCl droplet aerosol. No significant changes were seen during exposure to filtered air or NaCl droplet aerosol alone. The results suggest that the site of effect of the SO/sub 2/-NaCl droplet aerosol was in small airways. The asthmatic adolescents appeared to be more sensitive to the SO/sub 2/ droplet aerosol than were healthy nonsmoking adults previously studied.
Research Organization:
Univ. of Washington, Seattle
OSTI ID:
6637127
Journal Information:
Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:1; ISSN ENVRA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AEROSOLS
AGE GROUPS
ALKALI METAL COMPOUNDS
ANIMALS
ASTHMA
BIOLOGICAL EFFECTS
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISEASES
DISPERSIONS
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MAN
OXIDES
OXYGEN COMPOUNDS
PRIMATES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SODIUM CHLORIDES
SODIUM COMPOUNDS
SOLS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
VERTEBRATES