Effects of sulfur dioxide on pulmonary function in healthy nonsmoking male subjects aged 55 years and older

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668791384797· OSTI ID:6516562

Rondinelli, R C.A.; Koenig, J Q; Marshall, S G

To determine whether normal nonsmoking individuals aged 55 years or greater have heightened bronchial reactivity to inhaled SO/sub 2/, ten male subjects, 55 to 73 year of age, were exposed for 20 min at rest and 10 min during moderate exercise on a treadmill to the following: 1) NaCl droplet aerosol, or 2) 1.0 ppm of SO/sub 2/ and NaCl droplet aerosol. Seven of the subjects also were exposed to 0.5 ppm SO/sub 2/ and NaCl droplet aerosol. Significant decreases in forced expiratory volume in one sec (FEV/sub 1/) were seen 2-3 min post-exercise following all three test modes. The reduction in FEV/sub 1/ seen after NaCl aerosol + 1.0 ppm SO/sub 2/ was significantly greater than that seen after NaCl aerosol alone. The results show that men aged 55 years or older are somewhat more sensitive to NaCl aerosol + 1.0 ppm SO/sub 2/ than similarly exposed normal adolescents, but not nearly as sensitive as asthmatic subjects. This study also demonstrates that investigations of air pollutants and exercise can be undertaken in subjects of this age.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 6516562
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 48:4; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AIR POLLUTION
ANIMALS
BODY
CHALCOGENIDES
DYNAMIC FUNCTION STUDIES
EXERCISE
LUNGS
MAMMALS
MAN
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SENSITIVITY
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TOXICITY
VERTEBRATES