Binucleate cell formation induced by x irradiation. [Suspensions of mouse mammary carcinoma cells (FM3A)]
Journal Article
·
· Radiat. Res.; (United States)
The kinetics of binucleate cell formation and their relationship to the recovery of primary cell damage were investigated using mouse mammary carcinoma cells (FM3A) grown in suspension. The following results were obtained: (i) the percentage of binucleate cells increased with the dose to a maximum on the second or third day postirradiation when the rate of proliferation was at a minimum; (ii) the percentage of binucleate cells was smaller following two split doses (2 x 500 rad, at a 4-hr interval) than following a single (1000-rad) dose; and (iii) the percentage of binucleate cells decreased with treatment of the cells with Hanks' balanced salt solution (HBSS) immediately postirradiation (1000 rad). These results suggest that radiation-induced binucleate cell formation plays an important role in reproductive cell death.
- Research Organization:
- Kyushu Univ., Fukuoka, Japan
- OSTI ID:
- 6630787
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 76:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Binucleate cell formation correlates to loss of colony-forming ability in X-irradiated cultured mammalian cells
ESTIMATION OF THE CELLULAR LETHAL DOSE AND THE CRITICAL CELL NUMBER FOR THE C3H MOUSE MAMMARY CARCINOMA FROM RADIOSENSITIVITY STUDIES IN VIVO
Survival of mouse mammary gland transplants of normal, hyperplastic, and tumor tissues exposed to X-rays
Journal Article
·
Sun Nov 30 23:00:00 EST 1986
· Radiat. Res.; (United States)
·
OSTI ID:6928402
ESTIMATION OF THE CELLULAR LETHAL DOSE AND THE CRITICAL CELL NUMBER FOR THE C3H MOUSE MAMMARY CARCINOMA FROM RADIOSENSITIVITY STUDIES IN VIVO
Journal Article
·
Fri Jan 22 23:00:00 EST 1960
· Nature
·
OSTI ID:4188086
Survival of mouse mammary gland transplants of normal, hyperplastic, and tumor tissues exposed to X-rays
Journal Article
·
Wed Mar 31 23:00:00 EST 1982
· J. Natl. Cancer Inst.; (United States)
·
OSTI ID:7085330
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CELL CONSTITUENTS
CELL DIVISION
CELL NUCLEI
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GLANDS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
MALFORMATIONS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SUSPENSIONS
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
CELL CONSTITUENTS
CELL DIVISION
CELL NUCLEI
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GLANDS
IN VITRO
IONIZING RADIATIONS
IRRADIATION
MALFORMATIONS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SUSPENSIONS
TUMOR CELLS
VERTEBRATES
X RADIATION