Influence of 18 environmentally relevant polycyclic aromatic hydrocarbons and Clophen A50, as liver monooxygenase inducers, on the mutagenic activity of benz(a)anthracene in the Ames test
Journal Article
·
· Carcinogenesis (N.Y.); (United States)
In the presence of various liver S9 preparations induced by different polycyclic aromatic hydrocarbons, the weak carcinogen, benz(a)anthracene, exhibited mutagenic activities comparable to those of benzo(a)pyrene in the Ames test. A series of positive correlations were found between mutagenic activity and the hydroxylation products of benz(a)anthracene at the 3,4-, 5,6- and 8,9-positions, of which 5,6-position was the most pronounced one. Results suggest that the observed mutagenic activity is due mainly to the generation of K-region epoxides.
- Research Organization:
- Inst. fuer Hygiene und Arbeitsmedizin des Universitaetsklinikum, Essen, Germany
- OSTI ID:
- 6627184
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5:6; ISSN CRNGD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZANTHRACENE
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CONDENSED AROMATICS
ENZYME ACTIVITY
EPOXIDES
HYDROCARBONS
MAMMALS
METABOLIC ACTIVATION
MICE
MUTAGEN SCREENING
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RODENTS
SCREENING
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZANTHRACENE
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CONDENSED AROMATICS
ENZYME ACTIVITY
EPOXIDES
HYDROCARBONS
MAMMALS
METABOLIC ACTIVATION
MICE
MUTAGEN SCREENING
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RODENTS
SCREENING
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
VERTEBRATES