Characterization of sulpipride-displaceable sup 3 H-YM-09151-2 binding sites in rat frontal cortex and the effects of subchronic treatment with haloperidol on cortical D-2 dopamine receptors

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90613-V· OSTI ID:6623954

Kazawa, Tetsushi; Higuchi, Teruhiko ^[1]; Mikuni, Masahiko; Takahshi, Kiyohisa ^[2]; Arai, Ichiro; Yamauchi, Toshio ^[3]

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1. Saitama Medical School (Japan) National Institute of Neuroscience, Tokyo (Japan)
2. National Institute of Neuroscience, Tokyo (Japan)
3. Saitama Medical School (Japan)

We investigated the pharmacological properties of the sulpiride-displaceable binding sites labeled by {sup 3}H-YM-09151-2 in rat frontal cortex, compared to those in striatum. The IC{sub 50} value of ketanserin was 486 nM, which was apparently different from its affinity for the 5HT-2 receptor. Various dopamine antagonists showed almost the same inhibitory effects for binding site in frontal cortex and striatum. Sulpiride-displaceable {sup 3}H-YM-09151-2 binding sites were considered to be D-2 dopamine receptors. After subchronic treatment with haloperidol, the D-2 receptor density of frontal cortex increased to the same extent as striatum without significant change in apparent affinity.

• OSTI ID: 6623954
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 47:6; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AFFINITY
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL COMPOSITION
DOPAMINE
DRUGS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
PSYCHOTROPIC DRUGS
RATS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES