Chemical studies on tobacco smoke. LXIII. Use of radioactive tobacco isolates for studying the formation of smoke components
Journal Article
·
· J. Agric. Food Chem.; (United States)
Tobacco plants exposed to /sup 14/CO/sub 2/ during growth served as sources for radioactive phytosterols, neophytadiene, alkaloids, fatty acids and others. Techniques for the isolation and identification of these compounds included solvent distribution, gel-permeation chromatography, thin-layer chromatography in conjunction with radioscanning, and gas chromatography-mass spectrometry. The radioactive isolates were then incorporated into cigarettes, and their distribution patterns in the smoke were determined. A substantial portion of the labeled isolates was combusted to /sup 14/CO/sub 2/, in addition to being transferred intact into the smoke ''tars,'' and degraded to volatile organic compounds. Measurable quantities (less than 1%) were also converted to polynuclear aromatic hydrocarbons. The techniques utilized can serve as models for additional studies of this kind and lead to practical approaches for modifying smoke composition.
- Research Organization:
- Naylor Dana Inst. for Disease Prevention, Valhalla, NY
- OSTI ID:
- 6620529
- Journal Information:
- J. Agric. Food Chem.; (United States), Journal Name: J. Agric. Food Chem.; (United States) Vol. 26:1; ISSN JAFCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
552001* -- Public Health-- Tracer Techniques
99 GENERAL AND MISCELLANEOUS
AEROSOLS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBON 14
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON ISOTOPES
CARBON OXIDES
CARCINOGENESIS
CHALCOGENIDES
CHEMICAL ANALYSIS
CHEMICAL PROPERTIES
CHEMISTRY
COLLOIDS
DISPERSIONS
EVEN-EVEN NUCLEI
HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
NUCLEI
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
QUALITATIVE CHEMICAL ANALYSIS
RADIATION CHEMISTRY
RADIOISOTOPES
RESIDUES
SMOKES
SOLS
TOBACCO
TOBACCO SMOKES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES
99 GENERAL AND MISCELLANEOUS
AEROSOLS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBON 14
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON ISOTOPES
CARBON OXIDES
CARCINOGENESIS
CHALCOGENIDES
CHEMICAL ANALYSIS
CHEMICAL PROPERTIES
CHEMISTRY
COLLOIDS
DISPERSIONS
EVEN-EVEN NUCLEI
HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
NUCLEI
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
QUALITATIVE CHEMICAL ANALYSIS
RADIATION CHEMISTRY
RADIOISOTOPES
RESIDUES
SMOKES
SOLS
TOBACCO
TOBACCO SMOKES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES