Serial study of the concentration of misonidazole in human tumors correlated with histologic structure

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90437-5· OSTI ID:6619796

Rich, T A; Dische, S; Saunders, M I; Stratford, M R.L.; Minchinton, A

Multiple biopsies were obtained from eight patients with malignant tumors during a course of fractionated radiotherapy. An analysis of the total 2-nitroimidazole concentration and a histological examination of the biopsy sample was done on material which appeared macroscopically similar. The parts of the tumor biopsies showing necrosis were found to contain much lower concentrations of nitroimidazole when compared with those found in the samples with well-vascularized and apparently viable tumor. During the course of irradiation changes in misonidazole concentrations were not found when similar histological material was examined. The low values of misonidazole in necrotic regions in human tumors may partly account for the wide variation of misonidazole concentrations reported in the literature (percent tumor/plasma, mean 62.9 +- 34.4 STD). The clinical significance of the microscopic distribution of misonidazole in tumors in unknown but further work in this area may aid in predicting the usefulness of future radiosensitizers.

• Research Organization: Mount Vernon Hospital, Middlesex, England
• OSTI ID: 6619796
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:2; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOPSY
BLOOD
BLOOD PLASMA
BODY FLUIDS
CHEMICAL ANALYSIS
DATA
DATA COMPILATION
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
DRUGS
EVALUATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
HETEROCYCLIC COMPOUNDS
HISTOLOGY
IMIDAZOLES
INFORMATION
IRRADIATION
MATERIALS
MEDICINE
MISONIDAZOLE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PATIENTS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIZERS
RADIOTHERAPY
THERAPY