Effect of ozone on the postnatal development of lamb mucociliary apparatus

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Journal of Applied Physiology (1985); (USA)

OSTI ID:6613804

Mariassy, A T; Abraham, W M; Phipps, R J; Sielczak, M W; Wanner, A ^[1]

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1. Univ. of Miami, Miami Beach, FL (USA)

We determined whether exposure to O3 early in the postnatal period impairs the normal development of the mucociliary apparatus in lambs and whether such changes lead to prolonged abnormalities in mucociliary function. Lambs were exposed to air (controls) or to 1 ppm O3 for 4 h/day for 5 days during the 1st wk of life. Tracheal mucus velocity (TMV), a marker of lung mucociliary clearance, was measured in vivo at birth (0 wk) and up to 24 wk later, and tracheal secretory function was measured (in vitro) and the morphology of the tracheal mucosa was determined at 0 and 2 wk in both groups. In the control group, TMV increased 94% from 0 to 2 wk (P less than 0.05), continued to increase until reaching a plateau at 8 wk, and then remained constant from 8 to 24 wk. In contrast, O3-exposed lambs showed a 24% decrease in TMV from 0 to 2 wk (P less than 0.05 vs. control), and throughout the remaining time TMV remained below (P less than 0.05) that observed in control lambs. O3 exposure partially prevented the age-dependent decrease in basal secretion of tracheal macromolecules normally observed between 0 and 2 wk. These changes in secretory function were associated with a significant increase in tissue conductance (37%, P less than 0.05 vs. 0 wk), predominantly the result of active chloride secretion. The functional changes induced by O3 were associated with a retardation of the normal morphological development of the tracheal epithelium.

• OSTI ID: 6613804
• Journal Information: Journal of Applied Physiology (1985); (USA), Journal Name: Journal of Applied Physiology (1985); (USA) Vol. 68:6; ISSN 8750-7587; ISSN JAPHE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
CLEARANCE
DOMESTIC ANIMALS
EXCRETION
HYDROXY ACIDS
LUNG CLEARANCE
MAMMALS
MEMBRANES
METABOLISM
MUCOUS MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
OZONE
RESPIRATORY SYSTEM
RUMINANTS
SHEEP
THREONINE
TOXICITY
TRACHEA
VERTEBRATES