Prediction of the developmental toxicity hazard potential of halogenated drinking water disinfection by-products tested by the in vitro hydra assay

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Regulatory Toxicology and Pharmacology; (USA)

DOI:https://doi.org/10.1016/0273-2300(90)90022-4· OSTI ID:6612536

Fu, L J; Johnson, E M; Newman, L M ^[1]

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1. Jefferson Medical College, Philadelphia, PA (USA)

A series of seven randomly selected potential halogenated water disinfection by-products were evaluated in vitro by the hydra assay to determine their developmental toxicity hazard potential. For six of the chemicals tested by this assay (dibromoacetonitrile; trichloroacetonitrile; 2-chlorophenol; 2,4,6-trichlorophenol; trichloroacetic acid; dichloroacetone) it was predicted that they would be generally equally toxic to both adult and embryonic mammals when studied by means of standard developmental toxicity teratology tests. However, the potential water disinfection by-product chloroacetic acid (CA) was determined to be over eight times more toxic to the embryonic developmental portion of the assay than it was to the adults. Because of this potential selectivity, CA is a high-priority item for developmental toxicity tests in pregnant mammals to confirm or refute its apparent unique developmental hazard potential and/or to establish a NOAEL by the route of most likely human exposure.

• OSTI ID: 6612536
• Journal Information: Regulatory Toxicology and Pharmacology; (USA), Vol. 11:3; ISSN 0273-2300
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
TERATOGEN SCREENING
HYDRA
SENSITIVITY
ORGANIC HALOGEN COMPOUNDS
WATER POLLUTION
BIOLOGICAL INDICATORS
BY-PRODUCTS
DISINFECTANTS
DRINKING WATER
TOXICITY
ANIMALS
AROMATICS
CNIDARIA
COELENTERATA
GERMICIDES
HALOGENATED AROMATIC HYDROCARBONS
HYDROGEN COMPOUNDS
INVERTEBRATES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
POLLUTION
SCREENING
WATER
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560300 - Chemicals Metabolism & Toxicology