Development of relative potency estimates for PAHs and hydrocarbon combustion product fractions compared to benzo(a)pyrene and their use in carcinogenic risk assessments

Technical Report · Sat Sep 01 04:00:00 EDT 1990

OSTI ID:6611996

Thorslund, T W; Farrar, D

As an extension of the work started in a previous contract (EPA 68-02-4403, April 1988), various approaches for estimating the carcinogenic potency of polycyclic aromatic hydrocarbons (PAH) mixtures were investigated. The approach uses the two-stage model described in the previous contract work to convert the tumor incidence data in a variety of bioassays to a low-dose linear slope of the dose-response curve. The potency of mixtures and components of mixtures is expressed as a fraction of the potency of benzo(a)pyrene (B(a)P), which is treated as a reference standard. The basic assumption of the method is that the relative potency of the mixture is the weighted average of the relative potency of the components. The method is applied to data generated by a single group of investigators on lung cancer in female Osborne-Mendel rats induced by implantation of test material in the lung. Diesel engine exhaust, gasoline engine exhaust, flue gas condensate from coal-fired furnances and sidestream cigarette smoke were tested, along with their identified chemical components and solvent-extracted components. Of nine different procedures for evaluating the relative potency of combustion product mixtures from their components, the most accurate one assumes that the relative potency of the solvent-extracted fraction containing greater than three rings is equal to B(a)P.

• Research Organization: Clement International Corp., Fairfax, VA (United States)
• OSTI ID: 6611996
• Report Number(s): PB-93-161008/XAB; CNN: EPA-68-02-4601
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
AROMATICS
BENZOPYRENE
BODY
CARBONACEOUS MATERIALS
CARCINOGEN SCREENING
CHEMICAL ANALYSIS
COAL
COMBUSTION PRODUCTS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
DIAGNOSTIC TECHNIQUES
DIESEL ENGINES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ENERGY SOURCES
ENGINES
EVALUATION
EXHAUST SYSTEMS
FLUE GAS
FOSSIL FUELS
FUELS
GASEOUS WASTES
GASOLINE
HEAT ENGINES
HYDROCARBONS
INFORMATION
INTERNAL COMBUSTION ENGINES
LABORATORY ANIMALS
LIQUID FUELS
LUNGS
MAMMALS
MATERIALS
NEOPLASMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PETROLEUM PRODUCTS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
PUBLIC HEALTH
RATS
RESEARCH PROGRAMS
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
SCREENING
STATISTICAL DATA
TOBACCO PRODUCTS
VERTEBRATES
WASTES