Differential protection by WR2721 of skin versus growing cartilage following irradiation in weanling rats

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576884· OSTI ID:6611622

Constine, L S; Rubin, P; Gregory, P

The potential for radioprotection of growing cartilage by the thiophosphate WR2721 was evaluated in weanling rats using single fractions of irradiation. Protection of acute skin toxicity was monitored simultaneously. Single doses of 600, 1200, 1800, or 2400 cGy were administered to the left tibia of CrL:CD(SD)BR female rats in groups of 12. Identically treated groups were injected with 310 mg/kg WR2721 (2/3 the determined LD50/30) in a concentration of 26 mg/ml intraperitoneally 15 min prior to irradiation. Rats untreated or given WR2721 without radiation served as control groups. Radiographs of the irradiated and unirradiated tibiae for each animal were obtained weekly to the date of sacrifice at 80 days following the initial treatment. Skin toxicity was assessed weekly starting on the second week using Moulder's scale. No significant difference in bone growth as measured by tibial lengths for the WR2721-treated or untreated animals was observed. Skin toxicity including moist desquamation occurred in irradiated limbs and was substantially less in rats treated with WR2721. As opposed to previous work with cysteamine, WR2721 as administered had no significant radioprotective effect on tibial growth in weanling rats but substantially reduced the accompanying skin toxicity.

• Research Organization: Univ. of Rochester Cancer Center, NY
• OSTI ID: 6611622
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
CARTILAGE
CONNECTIVE TISSUE
DRUGS
ESTERS
GROWTH
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RADIATION PROTECTION
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SKELETON
SKIN
THIOPHOSPHORIC ACID ESTERS
TIBIA
TISSUES
TOXICITY
VERTEBRATES