Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Cancer Research; (USA)

OSTI ID:6610512

Giavazzi, R; Garofalo, A; Bani, M R; Abbate, M; Ghezzi, P; Boraschi, D; Mantovani, A; Dejana, E ^[1]

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1. Mario Negri Institute for Pharmacological Research, Bergamo (Italy)

This study has examined the effect of the cytokine interleukin 1 (IL-1) on metastasis formation by the human melanoma A375M in nude mice. We have found that human recombinant IL-1 beta (a single injection greater than 0.01 micrograms per mouse i.v. given before tumor cells) induced an augmentation of experimental lung metastases from the A375M tumor cells in nude mice. This effect was rapidly induced and reversible within 24 h after IL-1 injection. A similar effect was induced by human recombinant IL-1 alpha and human recombinant tumor necrosis factor, but not by human recombinant interleukin 6. 5-(125I)odo-2'-deoxyuridine-radiolabeled A375M tumor cells injected i.v. remained at a higher level in the lungs of nude mice receiving IL-1 than in control mice. In addition, IL-1 injected 1 h, but not 24 h, after tumor cells enhanced lung colonization as well, thus suggesting an effect of IL-1 on the vascular transit of tumor cells. These findings may explain the observation of enhanced secondary localization of tumor cells at inflammatory sites and suggest that modulation of secondary spread should be carefully considered when assessing the ability of this cytokine to complement cytoreductive therapies.

• OSTI ID: 6610512
• Journal Information: Cancer Research; (USA), Journal Name: Cancer Research; (USA) Vol. 50:15; ISSN 0008-5472; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AUGMENTATION
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CELL DIVISION
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL NEOPLASMS
GROWTH FACTORS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
KINETICS
LUNGS
LYMPHOKINES
MAMMALS
MAN
MELANOMAS
METASTASES
MICE
MITOGENS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TUMOR CELLS
VERTEBRATES