Kinetics and fate of /sup 111/In oxine-labeled platelets in patients with aortic aneurysms

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · Arch. Surg. (Chicago); (United States)

DOI:https://doi.org/10.1001/archsurg.1982.01380330032009· OSTI ID:6607344

Heyns, A D; Loetter, M G; Badenhorst, P N; Pieters, H; Nel, C J; Minnaar, P C

The survival and sites of sequestration of /sup 111/In oxine-labeled autologous platelets were studied quantitatively in six patients with aortic aneurysms. The in vivo distribution was quantitated daily with a scintillation camera and a computer-assisted imaging system. Data of platelet survival curves were fitted to a gamma function model. Mean platelet survival was shortened and the disappearance curves were exponential in all but two patients who had normal platelet survival. Platelet radioactivity in the aneurysm was 5.1 +/- 3% of whole-body radioactivity at the end of platelet survival. Platelet were sequestered in the spleen, liver, and bone marrow. Accumulation of platelets, presumably due to microembolization, was prominent in the lower limbs. This indicates that although platelets were deposited in the aneurysm, many are damaged and are eventually sequestered in the reticuloendothelial system.

• Research Organization: Blood Platelet Research Unit, South African Medical Research Council, Republic of South Africa
• OSTI ID: 6607344
• Journal Information: Arch. Surg. (Chicago); (United States), Journal Name: Arch. Surg. (Chicago); (United States) Vol. 117:9; ISSN ARSUA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
AORTA
ARTERIES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXINE
PATHOLOGY
PATIENTS
PYRIDINES
QUINOLINES
RADIOISOTOPES
RETICULOENDOTHELIAL SYSTEM
TISSUES
USES