/sup 111/In oxine-labeled rabbit platelets: in vivo distribution and sites of destruction

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Blood; (United States)

OSTI ID:6049858

Hill-Zobel, R L; Scheffel, U; McIntyre, P A; Tsan, M F

We have studied the kinetics, biodistribution, and fate of autologous platelets labeled with /sup 111/In-oxine in rabbits. The initial recovery was 75% and mean survival time was 2.8 days when the data were analyzed by the multiple-hit gamma function model. Using a modified geometric mean for correction of attenuation, there was good correlation between the values obtained by in vivo quantification and those obtained by postmortem measurements of the radioactivity in the liver and the spleen (i.e., r . 0.854 and 0.899, respectively, n . 32). Using this method, it was shown that after infusion, the /sup 111/In-platelets rapidly accumulated in these two organs reaching 35% and 12% of the injected dose in the liver and spleen, respectively, by 1 day. Thereafter, there was little subsequent change. On the sixth day, when essentially all of the /sup 111/In-platelets had cleared from the circulation, a total of 82% of the injected dose was deposited in the three major reticuloendothelial organs: liver (40%), spleen (14%), and bone marrow (28%). Our results suggest that in addition to liver and spleen, bone marrow played an important role in sequestering platelets in rabbits.

• Research Organization: Divisions of Radiation Health Sciences, The Johns Hopkins University, Baltimore, MD
• OSTI ID: 6049858
• Journal Information: Blood; (United States), Journal Name: Blood; (United States) Vol. 61:1; ISSN BLOOA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY FLUIDS
BONE MARROW
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HEMATOPOIETIC SYSTEM
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RABBITS
RADIOISOTOPES
SPLEEN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES