Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease

Journal Article · · Arteriosclerosis (Dallas); (United States)
; ; ; ; ;
The objective of this study was to examine multiple risk factors and correlated malignant neoplasms of blackfoot disease (BFD), a unique peripheral vascular disease related to continuous exposure to high-arsenic artesian well water. A total of 241 BFD cases, including 169 with spontaneous or surgical amputations of affected extremities, and 759 age-sex-residence-matched healthy community controls were studied to explore the risk factors of BFD. Multiple logistic regression analysis showed that artesian well water consumption, arsenic poisoning, familial history of BFD, and undernourishment were significantly associated with the development of BFD. The life-table method used to analyze cancer mortality of 789 BFD patients followed for 15 years showed a significantly higher mortality from cardiovascular diseases, peripheral vascular diseases, and cancers of bladder, skin, lung, and liver among BFD patients as compared with the general population in Taiwan or residents in the BFD-endemic area. The results imply the atherogenicity and carcinogenicity of the artesian well water in the BFD-endemic area.
Research Organization:
National Taiwan Univ. College of Medicine, Taipei (China)
OSTI ID:
6600093
Journal Information:
Arteriosclerosis (Dallas); (United States), Journal Name: Arteriosclerosis (Dallas); (United States) Vol. 8:5; ISSN ARTRD
Country of Publication:
United States
Language:
English

Similar Records

Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers
Journal Article · Thu Oct 31 23:00:00 EST 1985 · Cancer Res.; (United States) · OSTI ID:6289705
Blackfoot disease in Taiwan: a 30-year follow-up study
Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Angiology; (United States) · OSTI ID:5900905
Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases
Journal Article · Thu Nov 30 23:00:00 EST 1989 · American Journal of Epidemiology; (USA) · OSTI ID:5078153

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARSENIC
ASIA
CARCINOGENESIS
CARDIOVASCULAR DISEASES
CONTAMINATION
DIET
DISEASE INCIDENCE
DISEASES
DRINKING WATER
ELEMENTS
EPIDEMIOLOGY
HYDROGEN COMPOUNDS
ISLANDS
MATHEMATICS
NEOPLASMS
OXYGEN COMPOUNDS
PATHOGENESIS
POLLUTION
REGRESSION ANALYSIS
RISK ASSESSMENT
SEMIMETALS
STATISTICS
TAIWAN
TOXICITY
VASCULAR DISEASES
WATER
WATER POLLUTION
WATER WELLS
WELLS