Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases

Journal Article · Fri Dec 01 04:00:00 EST 1989 · American Journal of Epidemiology; (USA)

OSTI ID:5078153

Wu, M M; Kuo, T L; Hwang, Y H; Chen, C J ^[1]

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1. Institute of Biomedical Sciences, Taipei, Taiwan (China)

Age-adjusted mortality rates were analyzed to examine the dose-response relation between ingested arsenic levels and risk of cancers and vascular diseases among residents in the endemic area of blackfoot disease, a unique peripheral vascular disease associated with long-term exposure to high-arsenic artesian well water and confined to the southwestern coast of Taiwan. The arsenic levels in well water determined in 1964-1966 were available in 42 villages of the study area, while mortality and population data during 1973-1986 were obtained from the local household registration offices and Taiwan Provincial Department of Health. Age-adjusted mortality rates from various cancers and vascular diseases by sex were calculated using the 1976 world population as the standard population. A significant dose-response relation was observed between arsenic levels in well water and cancers of the bladder, kidney, skin, and lung in both males and females, and cancers of the prostate and liver in males. However, there was no association for cancers of the nasopharynx, esophagus, stomach, colon, and uterine cervix, and for leukemia. Arsenic levels in well water were also associated with peripheral vascular diseases and cardiovascular diseases in a dose-response pattern, but not with cerebrovascular accidents. The dual effect of arsenic on carcinogenesis and arteriosclerosis and the interrelation between these two pathogenic mechanisms deserve more intensive study.

• OSTI ID: 5078153
• Journal Information: American Journal of Epidemiology; (USA), Journal Name: American Journal of Epidemiology; (USA) Vol. 130:6; ISSN 0002-9262; ISSN AJEPA
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540320 -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARSENIC
ARTERIOSCLEROSIS
ASIA
CARDIOVASCULAR DISEASES
CONTAMINATION
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPIDEMIOLOGY
INGESTION
INTAKE
ISLANDS
MAMMALS
MAN
MORTALITY
NEOPLASMS
POLLUTION
PRIMATES
SEMIMETALS
TAIWAN
TOXICITY
VASCULAR DISEASES
VERTEBRATES
WATER POLLUTION
WATER SUPPLY
WATER WELLS
WELLS