Chronic damage after radiation therapy: challenge to radiation biology

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90394-8· OSTI ID:6599307

Trott, K R

After local irradiation of the heart or the recto-sigmoid of rats, chronic radiation damage develops after several months, leading to well-defined clinical syndromes of fatal pericarditis and myocardial necrosis or fatal ileus. In both organs, the LD-50 is below 20 Gy, and a pronounced split dose recovery has been measured with fractionated irradiation. In both organs, the primary radiation damage appears to be to the capillaries, which then leads to secondary parenchymal atrophy. Damage to structured vessels and fibrosis was only seen in areas of necrosis, which in the gut might be precipitated by secondary trauma to the atrophic mucosa.

• Research Organization: University of Munich, Neuherberg, West Germany
• OSTI ID: 6599307
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:6; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BLOOD VESSELS
BODY
CAPILLARIES
CARDIOVASCULAR SYSTEM
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
FIBROSIS
GASTROINTESTINAL TRACT
HEART
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
MEMBRANES
MUSCLES
MYOCARDIUM
NECROSIS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PERICARDIUM
RADIATION EFFECTS
RADIOBIOLOGY
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SEROUS MEMBRANES
SIDE EFFECTS
THERAPY
VERTEBRATES