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Radiation-induced heart disease in rats

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
After local irradiation of the rat heart with X ray doses of over 10 Gy (single dose), animals developed symptoms of radiation-induced heart disease, which at higher doses would lead to fatal cardiac failure. The LD 50 at 1 year was between 15 Gy and 20 Gy. The pericardium and epicardium responded to irradiation with exudative pericarditis after 4 months. Focal myocardial damage was secondary to progressive capillary damage.
Research Organization:
Abteilung fuer Strahlenbiologie der GSF, Neuherberg, Germany, F.R.
OSTI ID:
5474762
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:4; ISSN IOBPD
Country of Publication:
United States
Language:
English