A toxicological study of 1,2,4-triazole-5-one
Technical Report
·
OSTI ID:6598250
The acute oral LD/sub 50/ values for 1,2,4-triazole-5-one (TO) are greater than 5g/kg. According to classical guidelines, the material would be considered only slightly toxic or practically nontoxic in both rats and mice. The sensitization study in the guinea pig did not show TO to have potential sensitizing effects. Skin application studies on the rabbit demonstrated it was cutaneously nonirritating. This material was also nonirritating in the rabbit eye application studies. 4 refs., 1 tab.
- Research Organization:
- Los Alamos National Lab., NM (USA)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6598250
- Report Number(s):
- LA-11461-MS; ON: DE89004070
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DOSES
EVALUATION
EYES
FACE
GUINEA PIGS
HEAD
HETEROCYCLIC COMPOUNDS
INGESTION
INTAKE
LETHAL DOSES
MAMMALS
MATERIALS
MICE
MORTALITY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RABBITS
RATS
RODENTS
SENSE ORGANS
SKIN
SURVIVAL TIME
TOXIC MATERIALS
TOXICITY
TRIAZOLES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DOSES
EVALUATION
EYES
FACE
GUINEA PIGS
HEAD
HETEROCYCLIC COMPOUNDS
INGESTION
INTAKE
LETHAL DOSES
MAMMALS
MATERIALS
MICE
MORTALITY
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RABBITS
RATS
RODENTS
SENSE ORGANS
SKIN
SURVIVAL TIME
TOXIC MATERIALS
TOXICITY
TRIAZOLES
VERTEBRATES