A toxicological study of 1,2,4-triazole-5-one

Technical Report · Thu Dec 01 00:00:00 EST 1988

OSTI ID:6598250

London, J

The acute oral LD/sub 50/ values for 1,2,4-triazole-5-one (TO) are greater than 5g/kg. According to classical guidelines, the material would be considered only slightly toxic or practically nontoxic in both rats and mice. The sensitization study in the guinea pig did not show TO to have potential sensitizing effects. Skin application studies on the rabbit demonstrated it was cutaneously nonirritating. This material was also nonirritating in the rabbit eye application studies. 4 refs., 1 tab.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6598250
• Report Number(s): LA-11461-MS; ON: DE89004070
• Resource Relation: Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
INGESTION
EVALUATION
TRIAZOLES
BIOLOGICAL EFFECTS
ACUTE EXPOSURE
EYES
GUINEA PIGS
LETHAL DOSES
MICE
MORTALITY
ORGANIC COMPOUNDS
RABBITS
RATS
SKIN
SURVIVAL TIME
TOXIC MATERIALS
TOXICITY
ANIMALS
AZOLES
BODY
BODY AREAS
DOSES
FACE
HEAD
HETEROCYCLIC COMPOUNDS
INTAKE
MAMMALS
MATERIALS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology