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Factors affecting possible carcinogenicity of inhaled nitropyrene aerosols. Research report, July 1984-July 1987

Technical Report ·
OSTI ID:6598002
; ; ; ;
Tissue distribution of 1-nitropyrene was evaluated in rats after inhalation of pure compound or compound associated with gallium oxide particles. The influence of concomitant exposure to sulfur dioxide was also explored. There were no differences in tissue distribution if 1-nitropyrene was administered alone or in combination with gallium oxide particles, sulfur dioxide, or both. There was, however, a marked inflammatory and fibrogenic response to the gallium oxide. Alternatively, the effect of particle association on lung retention of 1-nitropyrene was investigated with the use of carbon black particles. The retention of /sup 14/C-1-nitropyrene adsorbed onto carbon black particles was higher than that of the compound inhaled as a pure aerosol. The amount of /sup 14/C that was bound to particles steadily decreased with time after exposure, compared to total lung /sup 14/C, indicating removal of the /sup 14/C from the particles.
Research Organization:
Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (USA). Inhalation Toxicology Research Inst.
OSTI ID:
6598002
Report Number(s):
PB-89-111777/XAB
Country of Publication:
United States
Language:
English

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Related Subjects

520200 -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON
CARBON 14
CARBON BLACK
CARBON ISOTOPES
CARCINOGENS
CHALCOGENIDES
COLLOIDS
CONDENSED AROMATICS
DISPERSIONS
DISTRIBUTION
DOCUMENT TYPES
ELEMENTS
EVEN-EVEN NUCLEI
GALLIUM COMPOUNDS
GALLIUM OXIDES
HYDROCARBONS
INHALATION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LABORATORY ANIMALS
LIGHT NUCLEI
METABOLISM
NONMETALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
PATHOLOGY
POLLUTION
PROGRESS REPORT
PYRENE
RADIOISOTOPES
RESPIRATION
SOLS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES