Role of cardiopulmonary mechanoreceptors in the postural regulation of renin

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/0002-9149(87)91112-X· OSTI ID:6596234

Sanchez, R A; Marco, E J; Oliveri, C; Otero, F J; Degrossi, O; Moledo, L I; Julius, S

To change the stretch on cardiopulmonary mechanoreceptors, large shifts of blood in the capacity space were elicited by tilting and by exerting positive lower body pressure in the tilted position. Twelve volunteers underwent invasive hemodynamic studies and in 10 other subjects cardiac size was determined by radionuclide cardiography. In all 22 subjects tilting caused the expected increase of renin, which was abolished by lower body compression. Decompression caused renin to increase again. Right atrial pressure in invasive studies and end-systolic and end-diastolic counts in noninvasive studies showed a significant and strong negative correlation with renin and norepinephrine levels. Thus, the degree of stretch of the cardiopulmonary mechanoreceptors is a major determinant of reflex regulation of renin release in humans.

• Research Organization: Hospital Instituto de Cardiologia, Buenos Aires, Argentina
• OSTI ID: 6596234
• Journal Information: Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 8; ISSN AJCDA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD PRESSURE
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
ELEMENTS
ENZYMES
HEART
HYDROLASES
METALS
NONSPECIFIC PEPTIDASES
ORGANS
PEPTIDE HYDROLASES
RADIOISOTOPE SCANNING
RENIN
SECRETION
SIZE
TECHNETIUM
TRANSITION ELEMENTS